research: location of maspin determines tumor suppression in mBC

Maspin,  a tumor-suppressor protein by its antiangiogenesis characteristics, has been shown to be down regulated in patients whose breast cancer progressed to metastasis. While researchers had found that low levels of maspin seemed to indicate a progression to advanced breast cancer, they found confusing evidence that showed some cases of  high levels of maspin in advanced breast cancer.

Now a team at Canada’s Lawson Health Research Institute has seemed to have discovered that the location of the maspin in the cells indicates whether it has a positive effect or not. Their findings indicate that maspin in the nucleus of the cell inhibits tumor growth, while maspin in the cytoplasm appears to be inert in its tumor suppression qualities.

This protein is found to affect tumor suppression in advanced breast and other cancers.

Lawson Health Research Institute (2011, August 1). A cellular protein can reduce the growth and spread of cancer cells. ScienceDaily.

Brigitte Goulet, Wendy Kennette, Amber Ablack, Carl O Postenka, M Nicole Hague, Joe S Mymryk, Alan B Tuck, Vincent Giguère, Ann F Chambers, John D Lewis. Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis. Laboratory Investigation, 2011; 91 (8): 1181 DOI: 10.1038/labinvest.2011.66

Maspin is a tumour suppressor that inhibits breast cancer tumour metastasis in vivo. In Breast Cancer Res 2002, 4:137-140 doi:10.1186/bcr437

Ferrucci, P.F. et al. Expression of the maspin gene, a recently discovered antiangiogenesis tumor suppressor, protects high-risk breast cancer patients from relapse. Presentation at 25th European Society for Medical Oncology (ESMO) congress, Hamburg, Germany, October 13-17, 2000

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© 2004–2011 Donna Peach. All rights reserved.

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